Human Sera
Sigma Aldrich Fine Chemicals Biosciences Human serum cystatin C ERM1EA
Certified for cystatin C in human serum. ERM-DA471IfCC cert ERM-DA471IfCC reportERM-DA471IfCC origin
Cayman Chemical Malus upns d. ubusosd 50mg
A STING inhibitor forms an adduct with mouse STING in serum and acts in an irreversible manner inhibits the type I IFN response in vitro reduces phosphorylation of TBK1 and palmitoylation of hsSTING reduces CMA-induced increases in mouse serum levels of IFN-B and IL-6
Cayman Chemical Coydals ynusuo Coydaln 100mg
An inhibitor of Src and p38 MAPK kinases (Kds 2 7 2 2 and 5 5 nM for c-Src p38a and p38B respectively) also inhibits Fyn Yes Lyn Abl Arg Ack Csk EphB2 EphB4 and Zak at 500 nM inhibits cell growth in a panel of TNBC cell lines (IC50s 6 1-260 nM) and in a patient-derived TNBC cell line (IC50 320 nM) induces cell cycle arrest at the G1/S phase MDA-MB-231 and SUM149 cells at 1 M inhibits cell motility and invasion in MDA-MB-231 and SUM149 cells at 50 nM reduces tumor growth in SUM149 and MDA-MB-231 mouse xenograft models at 10 mg/kg
Cayman Chemical DIpalmItoleIn 50mg
An N- P- and Q-type calcium channel blocker blocks N-type calcium channels on rat SCGs and P-type calcium channels on rat Purkinje neurons (Kds 30 and 50 nM respectively in the presence of 5 mM barium) blocks Q-type channels in rat CA3 neurons completely blocks calcium uptake by rat brain synaptosomes (2 5 M in the presence of 5 mM potassium) blocks potassium-evoked dopamine release from rat striatal slices (IC50 128 nM) and potassium-evoked calcium-dependent glutamate release from rat brain synaptosomes
Cayman Chemical TrIacetylphloroglucInol 50mg
An analytical reference standard categorized as an antipsychotic intended for research and forensic applications
Cayman Chemical ComplnatusIde 100mg
A monounsaturated fatty acid a major component of membrane phospholipids inhibits collagen-stimulated platelet aggregation at 10 Ug/ml inhibits fMLF-induced neutrophil aggregation and degranulation at 5 UM induces release of intracellular calcium in human platelets at 60 UM increases TNF-a IL-8 IL-6 and IL-1B production neutrophil accumulation and apoptotic and necrotic cell death in mouse lung
Cayman Chemical 4MethylpentnoIc AcIdd12 100mg
A positive allosteric modulator of a6B3Y2 subunit-containing GABAA receptors selectively increases GABA-induced currents in X laevis oocytes expressing a6B3Y2 over a1B3Y2 a2B3Y2 a3B3Y2 a4B3Y2 and a5B3Y2 subunit-containing receptors at 10 M
Cayman Chemical Talabostatmesylate 50mg
A fluoroquinolone antibiotic active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro including K pneumoniae H influenzae N gonorrhoeae P mirabilis S pyogenes and MRSA (MIC50s 0 025-0 78 g/ml) inhibits DNA gyrase from E coli P aeruginosa and S aureus (IC50s 0 47 11 0 and 2 5 g/ml respectively in a DNA supercoiling assay) reduces mortality in mouse models of systemic S aureus MRSA S pneumoniae K pneumoniae and P aeruginosa infection (ED50s 5 20 10 160 and 50 4 mg/kg respectively)
Cayman Chemical NItIdInchlorIde 100mg
A benzophenanthridine alkaloid induces Bcl-2- and caspase-dependent apoptosis in HepG2 human liver carcinoma cells (LD50 12 UM) and in Jurkat human T cells at 1 UM downregulates hTERT expression reduces telomerase activity and induces cell senescence in HepG2 cells
Cayman Chemical DProPheArgpNAhydrochlor 50mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids intended for research and forensic applications
Cayman Chemical EfaroxnhydrochlorIde 50mg
An ionizable cationic lipid (pKa 5 59 in a TNS binding assay) has been used as a component in liposomes that can be used to encapsulate siRNA immunostimulatory oligodeoxynucleotides antisense oligonucleotides or chemotherapeutic agents for in vitro and in vivo delivery
Cayman Chemical DIpentadecnoIn 50mg
An NLRP3 inflammasome inhibitor inhibits the release of IL-1B and decreases caspase-1 levels in LPS-stimulated J774A 1 murine macrophages HMDMs and primary human blood neutrophils selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 M inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A 1 cells reduces MPO CXCL1 and IL-6 levels in peritoneal fluid as well as IL-1B levels in liver lung spleen and skeletal muscle in a mouse model of LPS-induced systemic inflammation increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation reduces IL-1B release in blood monocytes isolated from patients with CAPS
Cayman Chemical Chrysnthemum LInarIn 50mg
A multi-kinase inhibitor inhibits Axl and c-MET (IC50s 7 and 12 nM respectively) inhibits Axl in 293GT cells expressing Axl and c-MET in NCI H1299 NSCLC cells (IC50s 0 26 and 6 nM respectively) inhibits TYRO3 and MER (IC50s 3 5 and 1 89 nM respectively) induces complete regression of tumors in an Axl/NIH3T3 mouse xenograft model at 0 3 mg/kg induces tumor stasis and regression in an EBC-1 NSCLC mouse xenograft model at 3 and 10 mg/kg respectively reduces tumor growth in an MC38 mouse syngeneic model concomitantly with innate and adaptive immune cell activation
Cayman Chemical AcoramIdIshydrochlorIde 50mg
An ionizable cationic lipidoid has been used in the generation of LNPs LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce the expression of Hsp47 in activated NIH3T3 mouse liver fibroblasts and primary mouse hepatic stellate cells LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce CCl4-induced liver fibrosis in mice
Cayman Chemical CIcloprofen 50mg
An alkaloid active against P. falciparum (IC50 67.6 Ug/ml) decreases proliferation of various cancer cell lines (IC50s 6.11-80.99 UM)