Human Sera
Cayman Chemical Betamethason 17-valerate 50mg
A glucocorticoid with anti-inflammatory activity; inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively); topical application of a 0.12% ointment blocks increases in EAr weight in a rat model of EAr edema induced by croton oil
Cayman Chemical DImaprIthydrochlorIde 100mg
A histamine H2 receptor agonist (Ki = 44 µM in guinea pig right atrium); selectively stimulates H2 over H1 and H3 receptors with relative potencies of 71, A. suum extract, which is not affected by pretreatment with mepyramine or cimetidine; stimulates gastric acid secretion in vivo in anaesthetized rats and cats with relative potencies of 19.5 and approximately 400 to 500, respectively, compared to histamine; inhibits 2-(2-pyridyl)ethylamine-induced bronchoconstriction in guinea pigs in a dose-dependent manner
Cayman Chemical R-CetIrIzInhydrochlorIde 50mg
A selective histamine H1 receptor antagonist; the (R)-enantiomer of cetirizine; binds to the H1 receptor with higher affinity than cetirizine (Kis = 3 and 6 nM, respectively) and is highly selective for H1 over M1-M5 receptors; decreases production of RANTES and eotaxin following antigen stimulation in mouse eosinophils in vitro (MEC = 0.05 µM); dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice (0.01-1% solution)
Cayman Chemical LabetalolhydrochlorIde 50mg
An analytical reference standard categorized as a β-adrenergic receptor antagonist; has been used as a doping agent in sports; intended for use in analytical forensic applications
Cayman Chemical LuteolosIde 50mg
A flavanoid with diverse biological activities; reduces LDH and caspase-3 activities and production of ROS and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury; blocks 3C protease activity (IC50 = 0.36 mM); reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM); inhibits the growth of HCC cells in vitro and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model at 2 mg/kg; reduces acanthosis and expression of epidermal differentiation markers in a mouse model of imiquimod-induced psoriasis
Cayman Chemical RCetIrIzInhydrochLRIde 100mg
A selective histamine H1 receptor antagonist; the (R)-enantiomer of cetirizine; binds to the H1 receptor with higher affinity than cetirizine (Kis = 3 and 6 nM, respectively) and is highly selective for H1 over M1-M5 receptors; decreases production of RANTES and eotaxin following antigen stimulation in mouse eosinophils in vitro (MEC = 0.05 µM); dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice (0.01-1% solution)
Cayman Chemical ValgncIclovIrhydrochLRIde 50mg
A prodrug form of ganciclovir; increases survival and reduces weight loss in an immunosuppressed hamster model of disseminated Ad5 infection at 200 mg/kg
Cayman Chemical S10hydroxyCamptothecIn 100mg
An inhibitor of topoisomerase I that demonstrates less toxicity than its parent compound; demonstrates strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM)
Meso Scale Discovery R-PLEX Human PR/PGR ASYQP
The R-Plex Human PR/PGR Assay from Meso Scale Diagnostics is a multiplex immunoassay that measures the levels of progesterone receptor (PR) and progesterone (PGR) in human serum plasma and cell culture supernatants This 10-plex assay utilizes electrochemiluminescence (ECL) detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements The assay can be run on Meso Scale Diagnostic s QuickPlex SQ 120 instrument and MESO QuickPlex SQ 120 Plates in as little as 3 hours This assay allows for the quantitative measurement of PR and PGR levels which can aid in monitoring hormone therapy and diagnosing hormone-related disorders
Cayman Chemical 6 7 4TrIhydroxyIsoflavon 100mg
An active metabolite of daidzein; suppresses anchorage-dependent and -independent growth of HCT116 and DLD-1 colon cancer cells, as well as induces cell cycle arrest at the S and G2/M phases in HCT116 cells from 12.5-100 µM; inhibits MDI-induced adipogenesis in 3T3-L1 preadipocytes at 40 and 80 µM; reverses scopolamine-induced memory impairments and increases hippocampal BDNF and CREB levels in mice at 5 mg/kg; prevents LPS-induced bone loss in mice
Cayman Chemical N2 N2-DImethylgunosIn 50mg
A methylated purine nucleoside; formed during the degradation of tRNA; serum levels are elevated in patients with AMML or large cell lung carcinoma
Cayman Chemical Tgogenn 100mg
A steroidal sapogenin with diverse biological activities; increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse BMSCs in a concentration-dependent manner; increases matrix calcium deposition in BMSCs at 30 and 90 μM; active against the fungus A. fumigatus (MIC50 = 16 μg/ml); inhibits carrageenan-induced paw edema in rats at 4.2 μg/kg
Miltenyi Biotec, Inc. MDSC Detection Kit, human
Detection and quantification of human MDSC subsets.
This product is subject to the following: Miltenyi Biotec, Inc. Terms and Conditions of Sale For Products and Services
Cayman Chemical BenzetImIdehydrochlorIde 100mg
A muscarinic acetylcholine receptor antagonist; induces mydriasis and inhibits pilocarpine-induced salivation and lacrimation in rats (ED50s = 0.06 and 0.04 mg/kg, respectively)