Human Sera
Cayman Chemical aDGalactose1phosphatepo 50mg
An intermediate in the interconversion of glucose and galactose
Cayman Chemical ClemIzolehydrochlorIde 50mg
An antihistamine that antagonizes the H1 receptor at high nanomolar concentrations; less potently blocks TRPC5 (IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels
Cayman Chemical NnonoylLHomoserIn lacto 50mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM
Cayman Chemical BetaxololhydrochlorIde 50mg
A β1-AR antagonist (Ki = 23 nM); selective for the β1-AR over the β2-AR (Ki = 790 nM); cytotoxic to 10.014 pRSV-T human corneal epithelial cells; reduces intraocular pressure in cynomolgus monkeys with ocular hypertension induced by laser trabeculoplasty at 150 UG/animal; inhibits veratridine-induced sodium influx in rat cortical synaptosomes (IC50 = 28.3 µM)
Cayman Chemical SB-269970hydrochlorIde 50mg
A potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors
Cayman Chemical 5trns Fluprostnl Isopropy 50mg
A potential impurity in commercial preparations of travoprost
Cayman Chemical SB-224289hydrochlorIde 50mg
A potent 5-HT1B inverse agonist (pKi = 8.16) that displays >75-fold selectivity for human 5-HT1B over all other 5-HT receptors
Cayman Chemical 2-OxoadIpIc AcId 50mg
An intermediate in the catabolism of L-tryptophan, L-lysine, and hydroxylysine; urinary excretion is increased in patients with α-ketoadipic aciduria
Cayman Chemical N 4ACTAmIdophenylIndomet 50mg
N-4AIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-4AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.1 and 0.625 µM, respectively.{8243,8513} It is about 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.
Cayman Chemical KetrolaccalcIum salt 100mg
An NSAID and COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of carrageenan-induced inflammation at 30 mg/kg; a racemic mixture of the active (S)-ketorolac and inactive (R)-ketorolac enantiomers
Cayman Chemical SulfosucInImIdyl MyrIstat 50mg
An inhibitor of fatty acid transport that has been used as an affinity label for certain membrane proteins that bind to fatty acids
Cayman Chemical PhenamIlmethnsulfonate 50mg
A TRPP3 inhibitor (IC50 = 140 nM); also inhibits ENaC (IC50 = 400 nM); decreases basal short-circuit currents in human and ovine bronchial epithelial cells (IC50s = 75 and 116 nM, respectively); inhibits potassium chloride-induced contractions in isolated rat endothelium-denuded aortic rings (EC50 = 6.76 µM) and increases contractile force in isolated rat right ventricular papillary muscles (EC50 = 16.98 µM); reduces pulmonary artery medial wall thickness and decreases right ventricular peak pressure in a rat model of chronic hypoxia-induced pulmonary hypertension at 15 and 30 mg/kg per day
Cayman Chemical NDemethylvncomycInhydroch 50mg
A glycopeptide antibiotic; active against several strains of S. aureus and S. epidermidis in vitro and in vivo